We showed here that formaldehyde generated by serine/1-carbon cycle metabolism contributed to the accumulation of toxic DNA-protein crosslinks (DPCs) in leukemia cells, especially in driver clones harboring oncogenic tyrosine kinases (OTKs: FLT3(internal tandem duplication ), JAK2(V617F), BCR-ABL1). Leukemia cells accumulate DNA damage, but altered DNA repair mechanisms protect them from apoptosis. Gupta, Jean-Yves Masson, Tomasz Skorski DNA polymerase θ protects leukemia cells from metabolically induced DNA damage. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M.
Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Please contact your CSM or if you have any additional questions.Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N. By March 1, learners will be unable to access Student Domains via Internet Explorer and will need to switch to a supported browser. Starting February 1, 2022, you and your students will begin seeing an in-app message alerting you to the change. What happens if I don’t switch to a supported browser?
By removing support, we will be able to release new features faster and with more reliability. Skilljar strives to create great products for our customers and supporting legacy browsers limits our ability to do so. Additionally, Internet Explorer does not receive security updates from Microsoft, making it an unsafe browser to use. Since Edge's release, Internet Explorer is no longer actively maintained by Microsoft and does not support many of the advanced web features necessary to build products that meet our customers' needs. In 2015, Microsoft replaced Internet Explorer with Microsoft Edge, a modern replacement for their legacy browser. Why is Skilljar retiring support of Internet Explorer? If you or your students access Student Domains via Internet Explorer, you will need to begin using one of our supported browsers. If you or your students are currently using Internet Explorer (IE) to log into Student Domains, please switch to a supported browser. Effective Febru, Skilljar will no longer support Internet Explorer or Internet Explorer Mode in Microsoft Edge on Student Domains.
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